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- Jeremy Bentham writes a paper entitled “Offences Against Oneself” arguing that consensual sexual acts between two adults in the privacy of a home should not be illegal.
- Fernanda Fernandez begins to notice she is developing masculine traits, and reports this to her superiors.
- At ten years old, George Gordon Byron inherits the title of Lord Byron and becomes a member of the landed gentry.
- The Publick Universal Friend is taken to court for blasphemy, but the courts rule that blasphemy is not against the law in the United States due to separation of church and state.
- Lord Byron begins writing poetry.
- September: Lord Byron refuses to return to Harrow, due to his romantic feelings for his cousin Mary Chaworth and her rejection of him.
- Anne Lister begins a romantic and sexual relationship with Eliza Raine.
- Lord Byron returns to school at Harrow.
- Lord Byron has a romantic relationship with his schoolmate John Thomas Claridge.
- Lord Byron leaves England for the “Grand Tour” of Europe. While on this journey, he claims to have slept with more than 200 men.
- James Barry begins living as a man, and enrolls at the University of Edinburgh.
- July 8: The White Swan is raided by the Bow Street Runners. 27 men are arrested.
- September 27: The Vere Street Coterie stands in the stocks and is brutalized by an angry mob of onlookers.
- Denmark decriminalizes homosexuality when it adopts Napoleon’s legal code.
- Lord Byron returns to England and learns that his former lover John Edleston has died. He attempts to resume his relationship with Claridge, but discovers he has become boring.
- March 11: John Newball Hepburn and Thomas White, of the Vere Street Coterie, are hung at Newgate Prison.
- Lord Byron becomes famous after the first two cantos of “Childe Harold’s Pilgrimage” are published. He begins an affair with Lady Caroline Lamb.
- James Barry graduates the University of Edinburgh and immediately enrolls in classes at United Hospitals of Guy’s and St. Thomas’.
- Lady Caroline Lamb returns to England from Ireland and very publicly tries to win back the affections of Lord Byron.
- The Phoenix of Sodom is published about the White Swan raid.
- July 2: James Barry passes examinations at the Royal College of Surgeons.
- July 6: James Barry is commissioned as a hospital assistant in the British army.
- January 2: Lord Byron marries Annabella Millbanke.
- December 7: James Barry is promoted to Assistant Surgeon to the Forces.
- January: Annabella Millbanke publicly separates from Lord Byron.
- February 12: John Hobhouse brings word to Lord Byron that rumors of his engaging in sodomy are beginning to emerge.
- James Barry is stationed in Cape Town, South Africa.
- April 25: Lord Byron leaves England.
- Lord Byron stays at Lake Geneva with a crew of his friends and fellow writers. Byron has a brief affair with Claire Clairmont.
- Claire Clairmont gives birth to Lord Byron‘s illegitimate daughter Allegra.
- Lord Byron has an affair with Margarita Cogni in Venice. When it ends, she drowns herself in the canal.
- Lord Byron travels to Greece to aid in the fight for Greek independence. He sells Rochdale Manor for 11,250 pounds and opens his coffers to the cause.
- February 28: Karl-Maria Benkert is born.
- Lieutenant General Charles Henry Somerset was accused of “buggering” James Barry. An investigation and trial follow.
- April 19: Lord Byron dies of a fever and sepsis.
- November 22: James Barry is promoted to Surgeon of the Forces and stationed in Mauritius.
- James Barry returns to South Africa to take care of Lieutenant General Charles Henry Somerset.
- Anne Lister is the first woman to climb Monte Perdido in the Pyrenees.
- Lieutenant General Charles Henry Somerset dies, and James Barry is sent to Jamaica.
- Anne Lister and Ann Walker became the first women and the first non-locals to climb Vignemale — the tallest mountain in the French Pyrenees.
- James Barry is promoted to Principal Medical Officer and is stationed in the West Indies.
- September 22: Anne Lister dies.
- December 25: Sallie and Patrick Hodgers have a child they name Jennie Irene Hodgers. (estimated year)
- James Barry contracts yellow fever and returns to England on sick leave.